Page 21 - NAMAH-Apr-2018
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Namah                          Turmeric: a natural anti-inflammatory tonic





        disease, celiac disease, gastritis and gastric ulcers.

        • Turmeric gradually lowers blood pressure, reduces LDL cholesterol levels, oxidative
        damage to the liver, blood vessels (atherosclerosis) and eyes.

        • Curcumin is used in the treatment of viral infections such as HIV, and Epstein Barr.

        • Since the discovery of turmeric’s antioxidant phenolic compounds and the protection these
        compounds provide against free radicals, this spice is now viewed as much more than just
        an ingredient in curry or a yellow dye. Curcumin extracted from turmeric has been found
        to down-regulate over 70 pro-cancer cell signalling pathways and oncogenes (11).

        Cancer: select clinical findings


                                   Cancer: select clinical data
                          Duration             Benefit                  Dosage
         Breast cancer   20 clinical   Data suggest significant   500 – 8,000 mg. of
                         trials      chemo preventative and     curcumin per day.
                                     anti-cancer potential for
                                     curcumin (12).             Standardised extracts in
                                                                lower amounts between
                                                                250-2,000 mg.
                         Six days    This study demonstrated that  T-47D cells were treated
                                     20–80 µM CUR significantly   with 5–80 µM CUR for
                                     downregulates both p53     a duration of 24 hours
                                     and ER protein levels with   along with variable
                                     a concomitant decrease in   amounts of curcumin.
                                     T-47D cell viability.


                                     CUR alone caused a 10-fold
                                     decrease compared to the
                                     treatment with oestrogen,
                                     which suggests its anti-
                                     proliferative effects (13).
                                     Curcumin killed breast     DK1 a curcumin
                                     cancer cells by arresting their  derivative’s, cytotoxicity
                                     development in various     was tested on breast
                                     phases of cell cycle and   cancer cell MCF-7 and
                                     growth and inducing cell   normal cell MCF-10A.
                                     death (14).



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